Hypertension (High Blood Pressure):
Definition:
High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.Blood pressure is determined both by the amount of blood your heart pumps and the amount of resistance to blood flow in your arteries. The more blood your heart pumps and the narrower your arteries, the higher your blood pressure.
You can have high blood pressure (hypertension) for years without any symptoms. Even without symptoms, damage to blood vessels and your heart continues and can be detected. Uncontrolled high blood pressure increases your risk of serious health problems, including heart attack and stroke.
High blood pressure generally develops over many years, and it affects nearly everyone eventually. Fortunately, high blood pressure can be easily detected. And once you know you have high blood pressure, you can work with your doctor to control it
Symptoms:
Most people with high blood pressure have no signs or symptoms, even if blood pressure readings reach dangerously high levels.A few people with high blood pressure may have headaches, shortness of breath or nosebleeds, but these signs and symptoms aren't specific and usually don't occur until high blood pressure has reached a severe or life-threatening stage.
Hypertension can lead to problems in the organs affected by high blood pressure. Long-term hypertension can lead to the following complications via arteriosclerosis, which causes narrowing of blood vessels by forming plaques:4,7
- An enlarged or weakened heart, to a point where it may fail to pump enough blood (heart failure)
- Aneurysm - an abnormal bulge in the wall of an artery
- Blood vessel narrowing - in the kidneys, leading to possible kidney failure; also in the heart, brain and legs, leading to potential heart attack, stroke or amputation, respectively
- Blood vessels in the eyes my rupture or bleed, leading to vision problems or blindness (hypertensive retinopathies, which can be classified by worsening grades one through four).
Fast facts on hypertension:
Here are some key points about high blood pressure. More detail and supporting information is in the body of this article.- Hypertension is a blood pressure higher than 140 over 90 mmHg (millimeters of mercury).
- One or both readings can be high, either the first, systolic reading (the pressure as the heart pumps blood around the body) or the diastolic one (as the heart relaxes and refills with blood).
- Modern lifestyle factors are responsible for a growing burden of hypertension: physical inactivity, salt-rich diets with processed and fatty foods, and alcohol and tobacco use.
- High blood pressure can also be secondary to other conditions - kidney disease, for example.
- Hypertension itself does not cause symptoms but in the long-term leads to complications caused by narrowing of blood vessels.
- Doctors diagnose high blood pressure over a number of visits using a sphygmomanometer, which involves applying an inflatable cuff to the upper arm.
- Lifestyle measures are used first to treat high blood pressure, including salt restriction, moderation of alcohol and other diet changes.
- One or more drugs from a number of different classes may be used for treatment.
What is hypertension (high blood pressure)?
Blood pressure is the force exerted by the blood against the walls of blood vessels, and the magnitude of this force depends on the cardiac output and the resistance of the blood vessels.The blood flowing inside vessels exerts a force against the walls - this is blood pressure.
We have more information on the biology and physics of normal blood pressure itself, a page that also looks at how it is measured, what normal measurements are, and how they change with age and exercise.
Hypertension is having a blood pressure higher than 140 over 90 mmHg, a definition shared by all the medical guidelines.
This means the systolic reading (the pressure as the heart pumps blood around the body) is over 140 mmHg (millimeters of mercury) or the diastolic reading (as the heart relaxes and refills with blood) is over 90 mmHg.
While this threshold has been set to define hypertension, it is for clinical convenience and because achieving targets below this level brings benefits for patients.6
But rather than being marked by a particular cut-off point, the medical expert committees on the condition actually see high blood pressure as having a continuous relationship to cardiovascular health.1,6
They believe that, to a point (down to levels of 115-110 mmHg systolic, and 75-70 mmHg diastolic) the lower the blood pressure the better.1
This view has led the American Heart Association (AHA), for example, to define the following ranges of blood pressure (in mmHg):
- Normal blood pressure is below 120 systolic and below 80 diastolic
- Prehypertension is 120-139 systolic or 80-89 diastolic
- Stage 1 high blood pressure (hypertension) is 140-159 systolic or 90-99 diastolic
- Stage 2 high blood pressure (hypertension) is 160 or higher systolic or 100 or higher diastolic
- Hypertensive crisis (a medical emergency) is when blood pressure is above 180 systolic or above 110 diastolic.
Causes of hypertension:
There are two types of high blood pressure.Primary (essential) hypertension:
For most adults, there's no identifiable cause of high blood pressure. This type of high blood pressure, called primary (essential) hypertension, tends to develop gradually over many years.Secondary hypertension:
Some people have high blood pressure caused by an underlying condition. This type of high blood pressure, called secondary hypertension, tends to appear suddenly and cause higher blood pressure than does primary hypertension. Various conditions and medications can lead to secondary hypertension, including:- Obstructive sleep apnea
- Kidney problems
- Adrenal gland tumors
- Thyroid problems
- Certain defects in blood vessels you're born with (congenital)
- Certain medications, such as birth control pills, cold remedies, decongestants, over-the-counter pain relievers and some prescription drugs
- Illegal drugs, such as cocaine and amphetamines
- Alcohol abuse or chronic alcohol use
High blood pressure leading to a diagnosis of hypertension will occur only when readings stay above normal all of the time.Having high blood pressure for a short amount of time is normal.
Blood pressure has a natural variation - it lowers during sleep and rises on awakening. It also rises in response to excitement, anxiety and physical activity.7
The disease burden of high blood pressure is a growing problem worldwide. The increases are blamed on lifestyle factors, including:1
- Physical inactivity
- A salt-rich diet through processed and fatty foods
- Alcohol and tobacco use.
- Age - everyone is at greater risk of high blood pressure as they get older. Prevalence of hypertension is higher in people over 60 years of age
- Race - African-American adults are at higher risk than white or Hispanic American adults
- Size - being overweight or obese is a key risk factor
- Sex - men and women have different risk profiles. While they have the same lifetime risks, men are more prone at younger ages while women are more prone at older ages
- Lifestyle - as mentioned above, this is to blame for growing rates of hypertension, from greater uptakes of dietary salt, excessive alcohol, low dietary potassium, and physical inactivity.
Specific causes of hypertension:
High blood pressure that has no known cause is termed primary hypertension (or essential hypertension). This is more common than secondary hypertension, which has an identified cause such as chronic kidney disease.Primary hypertension is unlikely to have a specific cause but multiple factors, including blood plasma volume and activity of the renin-angiotensin system, the hormonal regulator of blood volume and pressure - and primary hypertension is affected by environmental factors, including the lifestyle-related ones above.4
Secondary hypertension has specific causes - that is, it is secondary to another problem. One example, thought to be the most common, is primary aldosteronism, a hormone disorder causing an imbalance between potassium and sodium levels and so high blood pressure.4
Common reversible causes are excessive intake of alcohol and use of oral contraceptives, which can cause a slight rise in blood pressure; hormone therapy for menopause is also a culprit.7 Other secondary hypertensions are caused by:4,7
- Kidney disease
- Pheochromocytoma (a cancer)
- Cushing syndrome (which can be caused by use of corticosteroid drugs)
- Congenital adrenal hyperplasia (disorder of the adrenal glands, which secrete the hormone cortisol)
- Hyperthyroidism (overactive thyroid gland).
When to see a doctor:
You'll likely have your blood pressure taken as part of a routine doctor's appointment.Ask your doctor for a blood pressure reading at least every two years starting at age 18. Blood pressure generally should be checked in both arms to determine if there is a difference. Your doctor will likely recommend more frequent readings if you've already been diagnosed with high blood pressure or other risk factors for cardiovascular disease. Children age 3 and older will usually have blood pressure measured as a part of their yearly checkups.
If you don't regularly see your doctor, you may be able to get a free blood pressure screening at a health resource fair or other locations in your community. You can also find machines in some stores that will measure your blood pressure for free.
Public blood pressure machines, such as those found in pharmacies, may provide helpful information about your blood pressure, but they may have some limitations. The accuracy of these machines depends on several factors, such as a correct cuff size and proper use of the machines. Ask your doctor for advice on using public blood pressure machines.
Risk factors:
High blood pressure has many risk factors, including:- Age. The risk of high blood pressure increases as you age. Through early middle age, or about age 45, high blood pressure is more common in men. Women are more likely to develop high blood pressure after age 65.
- RACE High blood pressure is particularly common among blacks, often developing at an earlier age than it does in whites. Serious complications, such as stroke, heart attack and kidney failure, also are more common in blacks.
- Family history. High blood pressure tends to run in families.
- Being overweight or obese. The more you weigh the more blood you need to supply oxygen and nutrients to your tissues. As the volume of blood circulated through your blood vessels increases, so does the pressure on your artery walls.
- Not being physically active. People who are inactive tend to have higher heart rates. The higher your heart rate, the harder your heart must work with each contraction and the stronger the force on your arteries. Lack of physical activity also increases the risk of being overweight.
- Using tobacco. Not only does smoking or chewing tobacco immediately raise your blood pressure temporarily, but the chemicals in tobacco can damage the lining of your artery walls. This can cause your arteries to narrow, increasing your blood pressure. Secondhand smoke also can increase your blood pressure.
- Too much salt (sodium) in your diet. Too much sodium in your diet can cause your body to retain fluid, which increases blood pressure.
- Too little potassium in your diet. Potassium helps balance the amount of sodium in your cells. If you don't get enough potassium in your diet or retain enough potassium, you may accumulate too much sodium in your blood.
- Too little vitamin D in your diet. It's uncertain if having too little vitamin D in your diet can lead to high blood pressure. Vitamin D may affect an enzyme produced by your kidneys that affects your blood pressure.
-
Drinking too much alcohol. Over time, heavy
drinking can damage your heart. Having more than two drinks a day for
men and more than one drink a day for women may affect your blood
pressure.
If you drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger. One drink equals 12 ounces of beer, 5 ounces of wine or 1.5 ounces of 80-proof liquor.
- Stress. High levels of stress can lead to a temporary increase in blood pressure. If you try to relax by eating more, using tobacco or drinking alcohol, you may only increase problems with high blood pressure.
- Certain chronic conditions. Certain chronic conditions also may increase your risk of high blood pressure, such as kidney disease, diabetes and sleep apnea.
Although high blood pressure is most common in adults, children may be at risk, too. For some children, high blood pressure is caused by problems with the kidneys or heart. But for a growing number of kids, poor lifestyle habits, such as an unhealthy diet, obesity and lack of exercise, contribute to high blood pressure.
Complications:
The excessive pressure on your artery walls caused by high blood pressure can damage your blood vessels, as well as organs in your body. The higher your blood pressure and the longer it goes uncontrolled, the greater the damage.Uncontrolled high blood pressure can lead to:
- Heart attack or stroke. High blood pressure can cause hardening and thickening of the arteries (atherosclerosis), which can lead to a heart attack, stroke or other complications.
- Aneurysm. Increased blood pressure can cause your blood vessels to weaken and bulge, forming an aneurysm. If an aneurysm ruptures, it can be life-threatening.
- Heart failure. To pump blood against the higher pressure in your vessels, your heart muscle thickens. Eventually, the thickened muscle may have a hard time pumping enough blood to meet your body's needs, which can lead to heart failure.
- Weakened and narrowed blood vessels in your kidneys. This can prevent these organs from functioning normally.
- Thickened, narrowed or torn blood vessels in the eyes. This can result in vision loss.
- Metabolic syndrome. This syndrome is a cluster of disorders of your body's metabolism, including increased waist circumference; high triglycerides; low high-density lipoprotein (HDL) cholesterol, the "good" cholesterol; high blood pressure; and high insulin levels. These conditions make you more likely to develop diabetes, heart disease and stroke.
- Trouble with memory or understanding. Uncontrolled high blood pressure may also affect your ability to think, remember and learn. Trouble with memory or understanding concepts is more common in people with high blood pressure.
Tests and diagnosis:
To measure your blood pressure, your doctor or a specialist will usually place an inflatable arm cuff around your arm and measure your blood pressure using a pressure-measuring gauge.A blood pressure reading, given in millimeters of mercury (mm Hg), has two numbers. The first, or upper, number measures the pressure in your arteries when your heart beats (systolic pressure). The second, or lower, number measures the pressure in your arteries between beats (diastolic pressure).
Blood pressure measurements fall into four general categories:
- Normal blood pressure. Your blood pressure is normal if it's below 120/80 mm Hg.
- Prehypertension. Prehypertension is a systolic pressure ranging from 120 to 139 mm Hg or a diastolic pressure ranging from 80 to 89 mm Hg. Prehypertension tends to get worse over time.
- Stage 1 hypertension. Stage 1 hypertension is a systolic pressure ranging from 140 to 159 mm Hg or a diastolic pressure ranging from 90 to 99 mm Hg.
- Stage 2 hypertension. More severe hypertension, stage 2 hypertension is a systolic pressure of 160 mm Hg or higher or a diastolic pressure of 100 mm Hg or higher.
Your doctor will likely take two to three blood pressure readings each at three or more separate appointments before diagnosing you with high blood pressure. This is because blood pressure normally varies throughout the day, and sometimes specifically during visits to the doctor, a condition called white coat hypertension. Your blood pressure generally should be measured in both arms to determine if there is a difference. Your doctor may ask you to record your blood pressure at home and at work to provide additional information.
Your doctor may suggest a 24-hour blood pressure monitoring test called ambulatory blood pressure monitoring. The device used for this test measures your blood pressure at regular intervals over a 24-hour period and provides a more accurate picture of blood pressure changes over an average day and night. However, these devices aren't available in all medical centers, and they're rarely reimbursed.
If you have any type of high blood pressure, your doctor will review your medical history and conduct a physical examination.
Your doctor may also recommend routine tests, such as a urine test (urinalysis), blood tests, a cholesterol test and an electrocardiogram — a test that measures your heart's electrical activity. Your doctor may also recommend additional tests, such as an echocardiogram, to check for more signs of heart disease.
Taking your blood pressure at home
An important way to check if your blood pressure treatment is working, or to diagnose worsening high blood pressure, is to monitor your blood pressure at home. Home blood pressure monitors are widely available and inexpensive, and you don't need a prescription to buy one. Talk to your doctor about how to get started. Home blood pressure monitoring isn't a substitute for visits to your doctor, and home blood pressure monitors may have some limitations.Treatments and drugs:
Changing your lifestyle can go a long way toward controlling high blood pressure. Your doctor may recommend you eat a healthy diet with less salt, exercise regularly, quit smoking and maintain a healthy weight. But sometimes lifestyle changes aren't enough.In addition to diet and exercise, your doctor may recommend medication to lower your blood pressure.
Your blood pressure treatment goal depends on how healthy you are.
Blood pressure treatment goals*
Less than150/90 mm Hg: If you're a healthy adult age 60 or older.
Less than140/90 mm Hg: If you're a healthy adult younger than age 60.
Less than140/90 mm Hg If you have chronic kidney disease, diabetes or coronary artery disease or are at high risk of coronary artery disease.
*Although 120/80 mm Hg or lower is the ideal blood pressure goal, doctors are unsure if you need treatment (medications) to reach that level.
If you're age 60 or older, and use of medications produces lower systolic blood pressure (such as less than 140 mm Hg), your medications won't need to be changed unless they cause negative effects to your health or quality of life.
Also, people older than 60 commonly have isolated systolic hypertension — when diastolic pressure is normal but systolic pressure is high.
The category of medication your doctor prescribes depends on your blood pressure measurements and your other medical problems.
Medications to treat high blood pressure:
-
Thiazide diuretics. Diuretics, sometimes called
water pills, are medications that act on your kidneys to help your body
eliminate sodium and water, reducing blood volume.
Thiazide diuretics are often the first, but not the only, choice in high blood pressure medications. Thiazide diuretics include hydrochlorothiazide (Microzide), chlorthalidone and others.
If you're not taking a diuretic and your blood pressure remains high, talk to your doctor about adding one or replacing a drug you currently take with a diuretic. Diuretics or calcium channel blockers may work better for blacks and older people than do angiotensin-converting enzyme (ACE) inhibitors alone. A common side effect of diuretics is increased urination.
-
Beta blockers. These medications reduce the
workload on your heart and open your blood vessels, causing your heart
to beat slower and with less force. Beta blockers include acebutolol
(Sectral), atenolol (Tenormin) and others.
When prescribed alone, beta blockers don't work as well, especially in older adults, but may be effective when combined with other blood pressure medications.
- Angiotensin-converting enzyme (ACE) inhibitors. These medications — such as lisinopril (Zestril), benazepril (Lotensin), captopril (Capoten) and others — help relax blood vessels by blocking the formation of a natural chemical that narrows blood vessels. People with chronic kidney disease may benefit from having an ACE inhibitor as one of their medications.
- Angiotensin II receptor blockers (ARBs). These medications help relax blood vessels by blocking the action, not the formation, of a natural chemical that narrows blood vessels. ARBs include candesartan (Atacand), losartan (Cozaar) and others. People with chronic kidney disease may benefit from having an ARB as one of their medications.
-
Calcium channel blockers. These medications —
including amlodipine (Norvasc), diltiazem (Cardizem, Tiazac, others) and
others — help relax the muscles of your blood vessels. Some slow your
heart rate. Calcium channel blockers may work better for older people
and blacks than do ACE inhibitors alone.
Grapefruit juice interacts with some calcium channel blockers, increasing blood levels of the medication and putting you at higher risk of side effects. Talk to your doctor or pharmacist if you're concerned about interactions.
-
Renin inhibitors. Aliskiren (Tekturna) slows
down the production of renin, an enzyme produced by your kidneys that
starts a chain of chemical steps that increases blood pressure.
Tekturna works by reducing the ability of renin to begin this process. Due to a risk of serious complications, including stroke, you shouldn't take aliskiren with ACE inhibitors or ARBs.
Additional medications sometimes used to treat high blood pressure:
If you're having trouble reaching your blood pressure goal with combinations of the above medications, your doctor may prescribe:- Alpha blockers. These medications reduce nerve impulses to blood vessels, reducing the effects of natural chemicals that narrow blood vessels. Alpha blockers include doxazosin (Cardura), prazosin (Minipress) and others.
- Alpha-beta blockers. In addition to reducing nerve impulses to blood vessels, alpha-beta blockers slow the heartbeat to reduce the amount of blood that must be pumped through the vessels. Alpha-beta blockers include carvedilol (Coreg) and labetalol (Trandate).
- Central-acting agents. These medications prevent your brain from signaling your nervous system to increase your heart rate and narrow your blood vessels. Examples include clonidine (Catapres, Kapvay), guanfacine (Intuniv, Tenex) and methyldopa.
- Vasodilators. These medications, including hydralazine and minoxidil, work directly on the muscles in the walls of your arteries, preventing the muscles from tightening and your arteries from narrowing.
- Aldosterone antagonists. Examples are spironolactone (Aldactone) and eplerenone (Inspra). These drugs block the effect of a natural chemical that can lead to salt and fluid retention, which can contribute to high blood pressure.
Lifestyle changes to treat high blood pressure:
No matter what medications your doctor prescribes to treat your high blood pressure, you'll need to make lifestyle changes to lower your blood pressure.Your doctor may recommend several lifestyle changes, including:
- Eating a healthier diet with less salt (the Dietary Approaches to Stop Hypertension, or DASH, diet)
- Exercising regularly
- Quitting smoking
- Limiting the amount of alcohol you drink
- Maintaining a healthy weight or losing weight if you're overweight or obese
Resistant hypertension: When your blood pressure is difficult to control.
If your blood pressure remains stubbornly high despite taking at least three different types of high blood pressure drugs, one of which usually should be a diuretic, you may have resistant hypertension. People who have controlled high blood pressure but are taking four different types of medications at the same time to achieve that control also are considered to have resistant hypertension. The possibility of a secondary cause of the high blood pressure generally should be reconsidered.Having resistant hypertension doesn't mean your blood pressure will never get lower. In fact, if you and your doctor can identify what's behind your persistently high blood pressure, there's a good chance you can meet your goal with the help of treatment that's more effective.
Your doctor or hypertension specialist can evaluate whether the medications and doses you're taking for your high blood pressure are appropriate. You may have to fine-tune your medications to come up with the most effective combination and doses. Adding an aldosterone antagonist such as spironolactone (Aldactone) often leads to control of resistant hypertension. Some experimental therapies such as catheter-based radiofrequency ablation of renal sympathetic nerves (renal denervation) and electrical stimulation of carotid sinus baroreceptors are being studied.
In addition, you and your doctor can review medications you're taking for other conditions. Some medications, foods or supplements can worsen high blood pressure or prevent your high blood pressure medications from working effectively. Be open and honest with your doctor about all the medications or supplements you take.
If you don't take your high blood pressure medications exactly as directed, your blood pressure can pay the price. If you skip doses because you can't afford the medications, because you have side effects or because you simply forget to take your medications, talk to your doctor about solutions. Don't change your treatment without your doctor's guidance.
Lifestyle and home remedies:
Lifestyle changes can help you control and prevent high blood pressure, even if you're taking blood pressure medication. Here's what you can do:- Eat healthy foods. Eat a healthy diet. Try the Dietary Approaches to Stop Hypertension (DASH) diet, which emphasizes fruits, vegetables, whole grains, poultry, fish and low-fat dairy foods. Get plenty of potassium, which can help prevent and control high blood pressure. Eat less saturated fat and trans fat.
-
Decrease the salt in your diet. A lower sodium
level — 1,500 milligrams (mg) a day — is appropriate for people 51 years
of age or older, and individuals of any age who are black or who have
hypertension, diabetes or chronic kidney disease.
Otherwise healthy people can aim for 2,300 mg a day or less. While you can reduce the amount of salt you eat by putting down the saltshaker, you generally should also pay attention to the amount of salt that's in the processed foods you eat, such as canned soups or frozen dinners.
- Maintain a healthy weight. Keeping a healthy weight, or losing weight if you're overweight or obese, can help you control your high blood pressure and lower your risk of related health problems. If you're overweight, losing even 5 pounds (2.3 kilograms) can lower your blood pressure.
-
Increase physical activity. Regular physical
activity can help lower your blood pressure, manage stress, reduce your
risk of several health problems and keep your weight under control.
For most healthy adults, the Department of Health and Human Services recommends that you get at least 150 minutes a week of moderate aerobic activity or 75 minutes a week of vigorous aerobic activity, or a combination or moderate and vigorous activity. Aim to do muscle-strengthening exercises at least two days a week.
- Limit alcohol. Even if you're healthy, alcohol can raise your blood pressure. If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger. One drink equals 12 ounces of beer, 5 ounces of wine or 1.5 ounces of 80-proof liquor.
- Don't smoke. Tobacco injures blood vessel walls and speeds up the process of hardening of the arteries. If you smoke, ask your doctor to help you quit.
- Manage stress. Reduce stress as much as possible. Practice healthy coping techniques, such as muscle relaxation, deep breathing or meditation. Getting regular physical activity and plenty of sleep can help, too.
-
Monitor your blood pressure at home. Home blood
pressure monitoring can help you keep closer tabs on your blood
pressure, show if medication is working, and even alert you and your
doctor to potential complications. Home blood pressure monitoring isn't a
substitute for visits to your doctor, and home blood pressure monitors
may have some limitations. Even if you get normal readings, don't stop
or change your medications or alter your diet without talking to your
doctor first.
If your blood pressure is under control, you may be able to make fewer visits to your doctor if you monitor your blood pressure at home.
- Practice relaxation or slow, deep breathing. Practice taking deep, slow breaths to help relax. There are some devices available that promote slow, deep breathing. However, it's questionable whether these devices have a significant effect on lowering your blood pressure.
- Control blood pressure during pregnancy. If you're a woman with high blood pressure, discuss with your doctor how to control your blood pressure during pregnancy.
Coping and support:
High blood pressure isn't a problem that you can treat and then ignore. It's a condition you need to manage for the rest of your life. To keep your blood pressure under control:- Take your medications properly. If side effects or costs pose problems, don't stop taking your medications. Ask your doctor about other options.
- Schedule regular doctor visits. It takes a team effort to treat high blood pressure successfully. Your doctor can't do it alone, and neither can you. Work with your doctor to bring your blood pressure to a safe level, and keep it there.
- Adopt healthy habits. Eat healthy foods, lose excess weight and get regular physical activity. Limit alcohol. If you smoke, quit.
- Manage stress. Say no to extra tasks, release negative thoughts, maintain good relationships, and remain patient and optimistic.
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